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Researchers say they’ve located a “kill switch” that can trigger the death of cancer cells. Scientists at the UC Davis Comprehensive Cancer Center in Sacramento, California, have identified a protein on the CD95 receptor that can “program” cancer cells to die, as detailed in a study published in the journal Cell Death & Differentiation last month. A receptor is a protein within a cell that receives and transmits signals. LUNG CANCER PILL SHOWS ‘EARTH-SHATTERING’ RESULTS IN 5-YEAR STUDY: ‘AN OPTIMISTIC TIME’ CD95 receptors — also referred to as Fas — have gained the nickname “death receptors” because they send a signal that causes cancer cells to “self-destruct,” according to a press release from UC Davis. “Previous efforts to target this receptor have been unsuccessful. But now that we’ve identified this epitope (target), there could be a therapeutic path forward to target Fas in tumors,” Jogender Tushir-Singh, an associate professor in the Department of Medical Microbiology and Immunology and senior author of the study, said in the release. Experts are hopeful that future cancer drugs could boost the activity of these CD95 receptors to create a new weapon against cancer tumors, which have been treated historically with surgery, chemotherapy and radiation. WHY IMMUNOTHERAPY IS EMERGING AS THE ‘FOURTH PILLAR’ OF CANCER TREATMENTS, EXPERTS SAY Immune-based therapies, such as CAR (chimeric antigen receptor) T-cell therapy, have shown promise for a subset of patients, but have had limited effectiveness against many cancer types. “Despite being decently successful in liquid tumors, such as leukemia spectrum cancers, long-term remission remains the biggest challenge for CAR T-cell therapies,” Tushir-Singh told Fox News Digital in an email.  The bigger challenge with this therapy — which typically costs $500,000 or more — is that it has only shown “meager success” in treating solid tumors, the researcher noted. “Our study strongly provides a comprehensive takeaway and potential solution to transform the meager success of CAR-T therapies into potentially successful [therapies for] solid tumors.” NEW PROSTATE CANCER TREATMENT COULD BE ON THE HORIZON, SAY UK RESEARCHERS: ‘TREMENDOUSLY EXCITING’ The newly discovered “kill switch” could terminate tumor cells while also helping to make immunotherapies more effective — “a potential one-two punch against tumors,” the release stated. Thus far, no CD95-boosting drugs have made it into clinical trials. “Despite many breakthroughs in the cancer immunotherapeutic field, targeting Fas remains neglected, primarily due to fear of retaliation against immune-system T-cells,” Tushir-Singh told Fox News Digital. The study did have some limitations — namely, there is limited data from clinical trials, the researcher noted.  Tushir-Singh pointed out, however, that cancer researchers can now go back and collect human tumor samples from clinical trials and perform new analyses in light of these findings. CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER “It is evident that the success of CAR-T therapy relies on off-target killing by Fas,” he told Fox News Digital.  “With the current information, we researchers and doctors should screen potential cancer patients — who would be undergoing CAR-T therapy — to check for the comprehensive presence of Fas on their tumors,” he went on.  “If a patient lacks Fas expression in his or her tumors, we need to find ways to safely manipulate these tumors and start making them Fas before giving costly CAR therapies. The latter would likely make the CARs more potent in long-term efficacy.” Looking ahead, Tushir-Singh said he is hopeful for the future of cancer treatments. “Due to the advent of cancer immunotherapy and other targeted therapies, cancer rates overall in the past decades have decreased significantly,” he said.  “I read every day the outstanding research that is happening in the U.S. to beat cancer. People should stay positive.” Added Tushir-Singh, “The next breakthrough is just one experiment away.” For more Health articles, visit www.foxnews.com/health.



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Publish date : 2023-11-12 09:30:42

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Incumbent Republican Mississippi Governor Tate Reeves secured a second term at the helm of the Magnolia State after Democratic opponent conceded the race late Tuesday night. Reeves defeated Democrat Public Service Commissioner Brandon Presley — who is rock and roll legend Elvis Presley’s second cousin — in a contest closer than one might expect from ruby-red Mississippi. WHY THE GOVERNOR’S RACE IN MISSISSIPPI IS TURNING HEADS THIS YEAR Reeves touted his record as governor during a debate earlier this year, citing the state’s lowest unemployment rate in history, rising educational achievement levels and work with hospital leaders to prevent hospitals from closing. The Mississippi economy and healthcare, in particular Medicare expansion, became major issues in the race. Mississippi is the poorest state in the nation with a poverty rate of 18.1% in 2021, according to the U.S. Census Bureau. Nearly half of the state’s rural hospitals are in danger of closing. The health care crisis is at the forefront of the current election cycle and topped off Wednesday night’s debate. The candidates spent nearly 13 minutes of the one-hour debate discussing Medicaid and health care reform.  Democrats have hammered Reeves for refusing Medicaid expansion. Fox News asked Reeves his response to these attacks, and he said the state believes in work, not welfare. “I don’t believe that we should add 300,000 able-bodied adult Mississippians to the welfare rolls,” said Reeves. “I don’t think that’s good public policy. I don’t think it’s good public policy for a lot of reasons, one of which is it would not provide the financial windfall that Democrats claim that it would for our providers.” Presley’s platform included expanding Medicare. The Cook Political Report shifted the 2023 Mississippi governor’s race from “likely Republican” to “lean Republican” two weeks ago. Reeves won by just 5% in 2019, marking the most competitive governor’s race in the state since 2003. According to a poll conducted early last month by Magnolia Tribune/Mason-Dixon, 51% would vote for Reeves if the election “were held today,” and 43% would vote for Presley. The GOP governor secured his second term in a close contest that saw Reeves weather attacks over a massive corruption scandal that broke out while he served as lieutenant governor. Reeves has denied any involvement in the scandal that saw six members of the Mississippi Department of Human Services divert about $77 million in federal welfare money meant for residents in need to pet projects. Reeves ran a pair of TV ads accusing Presley of breaking the law by accepting money from a solar energy company under his purview as a public service commissioner. Presley called this ad a “bald faced lie” and called out Reeves’ ad during the debate. 



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Publish date : 2023-11-08 05:03:58

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The University of Michigan has reportedly sent information to the Big Ten claiming Rutgers, Ohio State and Purdue “engaged in communication about the Wolverines’ signals.” Prior to last year’s Big Ten championship game against Michigan, Purdue reportedly received offensive signals from OSU, while the New Jersey school allegedly sent defensive signals to the Boilermakers, accoring to ESPN. The new wrinkle in the case is not expected to affect any potential punishment for the Wolverines in their sign-stealing accusations. It also is unknown if these new allegations regarding Michigan’s Big Ten rivals violate NCAA rules or the conference’s sportsmanship policy. CLICK HERE FOR MORE SPORTS COVERAGE ON FOXNEWS.COM All four schools involved did not immediately respond to a request for comment. Michigan announced last week that Connor Stalions, the accused ringleader of an alleged sign-stealing scheme, resigned after earlier reports said he was fired.  It was revealed Oct. 18 the NCAA was investigating the football program for stealing signs. Since the investigation began, more damning evidence of Stalions’ alleged involvement has emerged. An unnamed former coach from college football’s Division III claimed Stalions gave him “a couple hundred dollars” for the recordings of the Wolverines’ future opponents, ESPN reported. The coach added that he received free tickets and shared the footage via an iPhone photo album.  SUPER BOWL CHAMP RIPS USC’S CALEB WILLIAMS FOR CRYING AFTER GAME: ‘COME ON, MAN’ Stalions was also alleged to be on the Central Michigan sideline when the team played Michigan State Sept. 1, wearing a bench credential that said “VB,” a visiting bench designation. This gives access for the credential holder to stand between the 20-yard lines, which is usually for players, coaches, team trainers and equipment staff.  It’s been reported Stalions purchased tickets to more than 30 games at 11 different Big Ten schools over the past three seasons, including this season. Michigan was not playing in any of the games for which Stalions bought tickets, sources told ESPN. The Big Ten sportsmanship policy states that the conference “expects all contests involving a member institution to be conducted without compromise to any fundamental element of sportsmanship. Such fundamental elements include integrity of the competition, civility toward all, and respect, particularly toward opponents and officials.” Michigan beat Rutgers, 31-7, Sept. 23 and the Boilermakers, 41-13, Saturday. The Wolverines face the Buckeyes in Ann Arbor Nov. 26. Michigan has beaten Ohio State two years straight after losing each of the previous eight matchups.



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Publish date : 2023-11-08 01:25:03

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Families of Israeli hostages held by Hamas inside Gaza appeared with lawmakers on both sides of the aisle Tuesday in Washington, D.C., to raise awareness for their loved ones, with one relative describing how a child celebrated his ninth birthday in captivity of terrorists.  Itay Raviv, speaking on the one-month anniversary of the Israel-Hamas war that began on Oct. 7, said getting the hostages released “should be the top priority of the entire world” and the “No. 1 thing that everyone discusses.”  “We don’t know again what their condition is. Ohad [Munder-Zichri] had a birthday two weeks ago on Oct. 23. He turned 9. He’s a smart, sweet boy who plays soccer and tennis and is very lovable,” Raviv said. “And he shouldn’t have spent his ninth birthday in captivity. He should not be in captivity at all.” Boaz Atzali then spoke about his 49-year-old cousin, Aviv, and wife Liat, whom he says adopted a three-legged special needs dog that was killed by Hamas militants during the Oct. 7 attack in southern Israel.  LIVE UPDATES: ISRAEL AT WAR WITH HAMAS  He told reporters in Washington that the killing of the animal demonstrates “what kind of cruelty” Hamas is capable of.  Atzali said what “breaks his heart” is that the couple has three kids, who now “lost both their parents on the same day.”  “They don’t know if they will ever see them again. They don’t know if they will get to hug them again,” he added.  At an event earlier with House Republican lawmakers, Doris Liber – the mother of Guy Iluz, a 26-year-old being held hostage – said the last words she heard on the phone from her son who was attending the music festival in southern Israel that was attacked by Hamas were “we are not going to survive it, nobody survived it, everybody was killed.”  “And I try to, tell him, ‘Guy, I love you,'” she continued. “Don’t worry. Nothing’s going to happen… I’m going to send somebody now to get you. And that’s what I did. I hung up and I regret that since I didn’t hear from him since.”  FAMILIES OF HAMAS HOSTAGES PLEAD FOR US ACTION  “I’m here because it’s been 30 days. Every day is like eternity to me. And I can’t wait any longer because I know that he was shot,” Liber added. “We don’t have a list of the hostages. We don’t know their condition. I don’t have anything, so I need your help.”  Yonatan Lulu-Shamriz, whose brother Alon is being held hostage, said on Oct. 7 that his younger brother wrote him a message saying terrorists entered his house in southern Israel.  “I wrote him that I love him and he’s strong. He send me a heart emoji. And that’s the last time we spoke,” he said.  “We need help now. We don’t know what is their condition. This is a call for action. And this is a wake-up call not only for Israel, not only for the Jewish community,” Yonatan Lulu-Shamriz added.  “This is a wake-up of all of you here, all of America, all of Europe. You are next. You are next. And we should do everything that we can to stop this atrocity.” 



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Publish date : 2023-11-07 20:35:53

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State Department staffers wrote a scathing internal memo urging the Biden administration to change its public stance toward Israel and support a ceasefire, Politico has reported. The leaked memo was submitted to the department’s Dissent Channel, where employees are invited to express policy disagreements, the outlet said. It is the latest incident showing internal strife within the department over the U.S. support for its closest ally in the Middle East. The message reportedly demands the U.S. support a ceasefire and be willing to publicly criticize “Israeli military tactics and treatments of Palestinians,” the outlet reported.  Staffers warned that the U.S. would appear a “biased and dishonest actor” in the war, if it did not air private criticisms of the Israel military. STATE DEPARTMENT OFFICIAL WHO RESIGNED OVER MILITARY AID TO ISRAEL DECRIES ‘WILLINGNESS TO ABANDON OUR VALUES’ “We must publicly criticize Israel’s violations of international norms such as failure to limit offensive operations to legitimate military targets,” the memo reportedly states. “When Israel supports settler violence and illegal land seizures or employs excessive use of force against Palestinians, we must communicate publicly that this goes against our American values so that Israel does not act with impunity.”” Politico reported that two midlevel staffers wrote this particular memo, but there were several other dissent memos over the Israel-Hamas war currently being shared within the department. The message “reflects the sentiments of many U.S. diplomats,” the report said. The State Department did not immediately return a request for comment on the matter. Fox News has previously reported disagreement within the State Department over the Israel-Hamas war.  Josh Paul, who worked for the State Department’s Bureau of Political-Military Affairs, resigned last month after Biden announced the U.S. would be supplying weapons to Israel. WOMAN IDENTIFIED AS STATE DEPARTMENT EMPLOYEE ACCUSES BIDEN ADMIN OF BEING ‘COMPLICIT’ IN ISRAEL ‘GENOCIDE’ “I cannot work in support of a set of major policy decisions, including rushing more arms to one side of the conflict, that I believe to be shortsighted, destructive, unjust, and contradictory to the very values that we publicly espouse,” he wrote to announce his resignation. A woman identified as a State Department employee has also accused President Biden and his administration of being “complicit in genocide” toward the people in Gaza and warned that it could stifle his re-election chances in 2024. “Hey @POTUS — so long as you keep showing absolute support for Bibi with no clear, actionable redlines or calls for ceasefire, you continue to support genocide,” Sylvia Yacoub wrote in one post on X. “Your rhetoric and approach from day one has resulted in the deaths of thousands. There is so much blood on your hands.” The Department previously declined to comment on social media posts by employees criticizing the U.S. policy toward Israel. However, spokesperson Matthew Miller said during a press briefing last month the department welcomes internal disagreements.  “We understand – we expect, we appreciate – that different people working in this department have different political beliefs, have different personal beliefs, have different beliefs about what United States policy should be. In fact, we think that’s one of the strengths of this government,” Miller said. “One of the strengths of this department is that we do have people with different opinions. We encourage them to make their opinions known. It, of course, is the President that sets policy, but we encourage everyone, even when they disagree with our policy, to let – to make their leadership know.” For more Culture, Media, Education, Opinion and channel coverage, visit foxnews.com/media.  Fox News’ Kyle Morris contributed to this report.



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Publish date : 2023-11-07 14:57:52

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More than 130 years after the father and stepmother of American woman Lizzie Borden were ax murdered in this Massachusetts city, true crime lovers, ghost hunters and history buffs all flock to the home where the double homicides took place. Located at 230 Second Street in eastern Massachusetts is The Historic Lizzie Borden House, now a working bed and breakfast. Lance Zaal, the owner of the Lizzie Borden house and president of U.S. Ghost Adventures, closed on the sale of the dwelling in May 2021. ON THIS DAY IN HISTORY, AUGUST 4, 1892, LIZZIE BORDEN’S FATHER AND STEPMOTHER ARE MURDERED IN MASSACHUSETTS “The reason I bought the house is [that] it fit perfectly with what we do with spooky haunted tours across the United States,” Zaal told Fox News Digital in an in-person interview.  “We had plans to do more with physical locations — and the Lizzie Borden house was the perfect opportunity to do that.” Zaal said it’s the customers’ reactions that fulfill him as he operates the tourist attraction. ODDEST HOMES IN AMERICA INCLUDE THE ‘SMURF HOUSE’ AND ONE THAT’S ‘LEGALLY’ HAUNTED “I love people’s excitement, how people think through the crime scene. They can retrace the steps of the people that lived here and of course they can remember the victims who didn’t receive the justice that they deserved.” The murders took place in Fall River on the morning of Aug. 4, 1892, according to Britannica. HALLOWEEN HORROR MOVIE HOMES AND THE STORIES BEHIND THEM: WOULD YOU DARE TO VISIT? Lizzie Borden’s mother died when she was a child.  Her businessman father, Andrew Borden, later remarried; his new wife’s name was Abby Borden.  It’s said that Abby Borden went upstairs to make a bed — and at some point during the morning hours, she was attacked with an ax-like weapon.  Guests of the bed and breakfast today have the option to sleep overnight in that room, just inches away from where Abby Borden’s body was found. ‘HAUNTED’ ROCKING HORSE THAT REPORTEDLY MOVED FROM ROOM TO ROOM ON ITS OWN IS GOING UP FOR SALE The head of the ax — the murder weapon — was later found in the basement of the Borden home, according to Zaal. Andrew Borden came home early that day and was murdered on the couch after his wife was murdered.  While the amount of blows the couple suffered isn’t clear, it’s been estimated by various sources that they may have been struck 10 to 20 times. The only people who were home, aside from the two victims, were Lizzie Borden and the family’s 25-year-old maid, Bridget Sullivan, whom the family called Maggie, according to staff members who currently work at The Historic Lizzie Borden House. Several facts in the case suggest that Lizzie Borden may have been guilty, as written in an online article published by the UMKC School of Law titled, “Fourteen Reasons to Believe Lizzie Murdered Her Parents.” LITERARY LEGEND HAUNTED HOTEL FOR 53 YEARS UNTIL NEGLECTED REMAINS BURIED WITH FAMILY IN NYC, SAY HISTORIANS Lizzie Borden reportedly had a “strained relationship” with stepmother Abby Borden, and some money and property disputes existed in the family.  Also, Lizzie Borden was witnessed attempting to buy poison at a local drugstore, one day before the murders. Lizzie Borden became a prime suspect. She was arrested on Aug. 11, 1892, according to the Library of Congress.  She was found not guilty on June 20, 1893, in a trial by a jury of 12 men. IOWA SCHOOL-TURNED-MASSIVE MANSION HITS REAL ESTATE MARKET FOR $1.75M Staff members at the house say the evidence was circumstantial. “Although acquitted of the charges against her, the question of whether Lizzie Borden committed the murders remains to this day,” the Library of Congress wrote online. Andrew Borden reportedly had purchased his family home in 1872 due to its convenient location to his business. “Today, the house is just as it was,” The Historic Lizzie Borden House website states. “The furnishings retain their rightful place, the décor has been painstakingly duplicated, and the original hardware and doors are still intact.” WOMAN GOES VIRAL FOR UNCOVERING ‘WEIRD’ HOMES FOR SALE ON ZILLOW: ‘IT HAS TAKEN OFF’ “Artifacts from the murder case are displayed while memorabilia from the era line shelves and mantel tops,” says the site. “A visitor is literally transported back to that morning when a perfect storm of events culminated in a double murder.” Fox News Digital got a look inside the three-floor home, which has no hallways at all. Any visitor must go through one bedroom to get to another. ON THIS DAY IN HISTORY, AUGUST 31, 1888, JACK THE RIPPER CLAIMS HIS FIRST VICTIM Photos of the Borden family grace the walls — and images of the actual crime scenes are even displayed in the rooms where the ax murders occurred.  The restoration done to the house provides an eerie sense of what it must have been like to be present that day in 1892. 10 BEST FALL GHOST TOURS FOR SPINE-TINGLING FUN IN AMERICA Zaal and his staff of Borden aficionados run daily tours and overnight stays. Rates range from $285 to $311 per night depending on the room chosen. Guests can stay in the Lizzie and Emma suite (Lizzie Borden and her sister’s rooms, which are separated by one door only); the Andrew and Abby suite; the Andrew Jennings room (dedicated to the defense attorney for Lizzie Borden); the John Morse room (Andrew Borden’s brother, who was staying at the house during the murders); the Hosea Knowlton room (in the attic, dedicated to the lead prosecutor in the Borden trial); or the Bridget Sullivan room (where the family’s maid slept). PARANORMAL TIKTOKS DEBUNKED! MAGICIAN AND CONTENT CREATOR REVEAL HOW ‘GHOSTLY’ VIDEOS ARE ACTUALLY MADE Zaal noted that the room of Bridget Sullivan, the family’s maid, is where guests report a ton of paranormal activity — with claims of music boxes sounding off and furniture being found moved across the room without a human in sight. Check-in is at 5:00 p.m. and check-out is at 10:00 a.m.  To receive breakfast, guests must be seated in the dining room by 8:30 a.m. The entire home or a floor can also be rented for events such as weddings or other occasions. Zaal said that summer and the Halloween seasons are typically the busiest, which explains why October was nearly booked solid this year.  Some rooms are still available on certain dates in November for those who are still searching for a spooky experience before winter arrives this year. ‘ANGELS, DEMONS, SPIRITS AND SOULS DO EXIST,’ SAYS EXORCIST PRIEST WHO WARNS AGAINST OUIJA BOARD USE “I would say in the most popular month in October, we have probably seen 6,000 visitors coming through the house,” Zaal said.  “We’ve added new experiences here at the house and one of those is a ghost hunt that we offer nightly from 10:00 p.m. to midnight. And we just added ghost hunts from midnight to 2:00 a.m.” Zaal’s company, U.S. Ghost Adventures, is currently in 80 cities across America with various creepy-cool offerings for people to experience.  But with his acquisition of the Lizzie Borden house, Zaal and his team created a special ghost tour to explore the city of Fall River. CLICK HERE TO SIGN UP FOR OUR LIFESTYLE NEWSLETTER “[The] Lizzie Borden house is just part of the city and just part of the city’s story,” he said. “We wanted to tell more about that story, about where Lizzie Borden was from, and where her family was from,” Zaal said. The gift shop sells hats, T-shirts, a “bloody” ax, mugs, bumper stickers, a Lizzie Borden board game, a bobblehead doll, refrigerator magnets and more.  Zaal said he plans on expanding guests’ experiences with more nightly ghost tours of the home, outdoor ax throwing, Victoria-era murder mystery nights and much more. Zaal promises an immersive, enjoyable and hauntingly good time with an accommodating staff that’s chock-full of Lizzie Borden knowledge. He also encourages visitors to record any spine-chilling encounters that may occur while they’re sleeping in the Lizzie Borden house. For more Lifestyle articles, visit www.foxnews.com/lifestyle.



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Publish date : 2023-11-07 10:15:45

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